Automated Media Fill Inspection
Reinraum
Abstract
The gold standard for media fill inspection is still manual turbidity checks. Although multiple technologies are available, only a few companies have taken advantage of them. This article provides a summary of the status quo of the process and presents an automated approach using tunable diode laser absorption spectroscopy, an already established technology for container closure integrity testing (USP1207). Since all microorganisms in question produce carbon dioxide, the growth of the organisms can be detected in the headspace by measuring an increase in carbon dioxide concentration. The growth of microorganisms was demonstrated with glass vials and continuous measurements. Thereby, various growth speeds and different growth behaviors from different microorganisms could be analyzed.
Correspondence:
Michael Mettraux
Wilco AG, Rigackerstr. 11, 5610 Wohlen
Michael.mettraux@wilco.com
 | Dr. Matthias Kahl leads R&D and LabServices at Wilco AG. Since joining Wilco in 2017, he has been instrumental in driving new technology development and aligning R&D initiatives with long-term business goals. He holds a Ph.D. in optics and laser technology from the University of Konstanz and a degree in physics from the University of Erlangen, with a specialization in solid-state physics and metrology. Prior to Wilco, he helped scale high-precision laser material processing operations as Deputy Development Manager. |
 | Michael |
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