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Application of Computed Tomography for In-Depth Investigation of Freeze-Dried Products
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Importance of Computed Tomography in Pharmacy Current Status of CT in Freeze-Drying Applications Possible Turnkey Role of CT Technology for the Future of Freeze-Drying Challenges in Freeze-Drying Applications Conclusion
Key Words: Computed Tomography, Freeze-Drying, Morphology, Quality assessment, Lyophilisation
Teresa Siegert1 and Henning Gieseler2 · 1Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen · 2GILYOS GmbH, Würzburg
Correspondence:
Teresa Siegert, Friedrich-Alexander-Universität Erlangen-Nürnberg, Lehrstuhl für pharmazeutische Technologie und Biopharmazie, Cauerstr. 4 Haus 6/Room 1 643, 91058 Erlangen (Germany); e-mail: teresa.siegert@fau.de
Abstract
3-dimensional images using computed tomography (CT) provide a valuable, non-invasive insight into the inner morphology of freeze-dried products. This technology allows the pore structure to be visualised in a similar way as obtained from scanning electron microscopy and enables the (...)
