Effect of Scoring Design on the Uniformity of Extended Release Matrix Tablet Halves
Efsun Duman a* , Nilufer Yuksel a* , Bryan Olin b , and Adel Sakr a
Industrial Pharmacy Program, College of Pharmacy, University of Cincinnati a , Cincinnati, OH (USA), and Procter & Gamble Pharmaceuticals b , Cincinnati, OH (USA)
* Present address: Ankara University, Faculty of Pharmacy, Pharmaceutical Technology Department, Ankara (Turkey)
Effekt des Bruchkerbendesigns auf die GleichfÃ¶rmigkeit von gleichmÃ¤Ãig verzÃ¶gert freisetzenden Matrix-TablettenhÃ¤lften
API030611 is an antiaxiety agent that needs to be titrated/adjusted relative to patientsâ responses and tolerances. The research objective was to evaluate the effect of scoring design on weight and content uniformity and dissolution of the extended release matrix tablet halves. Various scoring designs of capsule shaped tablets were evaluated. Ten subjects varying in age, weight and gender broke the scored tablets the same way like in the usual life. Certain scoring designs produced qualitatively more uniform tablet halves; there were no statistical differences due to scoring design, age, weight and gender. The most reproducible tablet halves were produced using the design of top and bottom scoring independent of the type (deep, shallow) of the scoring.
Key words Extended release Â· Half tablets, uniformity Â· Matrix tablets Â· Scoring design
pharmind 2000, Nr. 7, Seite 547