A Corn Starch / a-Lactose Monohydrate Compound as a New Directly Compressible Excipient
Karl G. Wagner and Jochen A. Dressler
Department of Pharmaceutical Technology (Prof. Dr. Peter C. Schmidt), Eberhard Karl University, Tübingen (Germany)
The purpose of this study was to compare the tableting properties of a new co-processed excipient for direct compression (StarLac®, in the following briefly called "SL") prepared from 15 % corn starch and 85 % a-lactose monohydrate against a physical mixture of the two components. The co-processed material and the physical mixture alone and in combination with two drugs, ascorbic acid and paracetamol, were tested for their powder and tablet properties, like flowability, crushing strength, friability and disintegration time. Additionally, the compaction properties were investigated recording the ejection force, the ratio of lower to upper compaction force and the upper punch displacement. The Heckel model was further used for analysis.
Key words Ascorbic acid · Corn starch · a-Lactose monohydrate · Paracetamol · StarLac® ·
pharmind 2002, Nr. 9, Seite 992