Privatsphäre-Einstellungen

Ein neues Prinzip zur Erzeugung von Aerosolen für die Inhalationstherapie

Teil 1: Zerstäubung von Flüssigkeiten mit einer nicht angepaßten Lavaldüse in einer stationären Gasströmung

Roman Messerschmid^a, Manfred Wolf^a, Klaus-Jürgen Steffens^a und Klaus List^b

Pharmazeutisches Institut, Pharmazeutische Technologie, Rheinische Friedrich-Wilhelms-Universität^a, Bonn, und IBL GmbH^b(Ingenieurbüro List), Reichelsheim

New Principle for the Generation of Aerosols for Inhalation Therapy / Part 1: Atomization of liquids with an overexpanding Laval nozzle in stationary gas flow During the relaxation gasflow through a laval nozzle with given theoretical outlet gas pressure a shockwave occurs inside the nozzle. This shockwave is accompanied by a dramatic change of velocity, pressure, density, temperature and entropy within few micrometers of flow. Through small drill holes the pressure inside the nozzle is monitored at multiple points and the shockwave is proven experimentally. By passing through the nozzle droplets with a coarse distribution are broken up into a fine aerosol. So it is possible to obtain an aerosol of only a few micrometers droplet size using relatively low pressure and high liquid flowrates.
In a laboratory assembly the useability of the Laval nozzle for the generation of an inhalation aerosol is investigated. The size distribution of the produced aerosol is characterised by laser diffraction.

Key words Aerosol · Inhalationsaerosol · Lavaldüse · Zerstäubung · Zweistoffdüse