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Granulierung hydrophober Wirkstoffe im Planetwalzenextruder

Rudolf Schroeder¹ und Klaus-Jürgen Steffens²

L.B.Bohle Maschinen und Verfahren GmbH¹, Ennigerloh, und Pharmazeutisches Institut, Pharmazeutische Technologie, an der Rheinischen Friedrich-Wilhelms-Universität², Bonn

Granulation of Hydrophobic Actives with the Planetary Roller Extruder

For hydrophobic actives the binder granulation is a widespread method to achieve sufficient tabletting properties. An intensive contact between binder and active during granulation is a prerequisite for a successful granulation due to the mostly hydrophilic behavior of the common used binders. This present article describes the possibility of granulations with very low binder concentrations in the planetary roller extruder, leading to a good tabletability of the granules. In the same way the tablets show outstanding disintegration properties and dissolution profiles while the active concentration in the final dosage form is up to 92 % .

Key words Granulierung, kontinuierliche · Tablettiereigenschaften · Wirkstoffe, hydrophobe