Hot Melt Technology
2nd Communication: Effect of Manufacturing Method on Tablet Characteristics1)
Heba Guirgis a, Bianca Broegmann b, and Adel Sakr a
Industrial Pharmacy Graduate Program, College of Pharmacy, University of Cincinnati a, Cincinnati, Ohio (USA), and Mundipharma GmbH b, Limburg (Germany)
A full factorial design has been implemented to study the characteristics of granules and tablets prepared by the hot melt technology using the high shear mixer/granulator (HSMB) and the fluid bed processor (FBP). The results were compared with those obtained by direct compression. Granules consisting of theophylline monohydrate and lactose granulated with polyvinylpyrrolidone solution were used as substrate. Hot melt excipients: cetostearyl alcohol (CSA, Lanette® O) and glyceryl behenate (GB) were evaluated using the three manufacturing techniques.
Key words Cetostearyl alcohol · Glyceryl behenate · Granulation, direct compression, fluid bed processing, high shear mixer · Hot melt technology
Â© ECV- Editio Cantor Verlag (Germany) 2001
pharmind 2001, Nr. 5, Seite 499