General principles and methodologies, regulatory aspects and applications (Part 2)*)
Peter Langguth, Staudinger Weg 5, 55099 Mainz, Germany; e-mail: firstname.lastname@example.org
4.2 Deconvolution methods
4.2.1 Mass balance methods
Mass balance methods are the oldest methods to determine the fraction of dose absorbed. They are model dependent, relatively comprehensible and for this reason still frequently used. Mass balance methods are based on the following assumption:
Amount of drug absorbed = amount of drug in body + amount of drug eliminated.
This means that drug which has been (...)