Kompressions- und Desintegrationseigenschaften von Tabletten mit digestiven Enzymen mikrobiellen Ursprungs1. Mitteilung: Physikochemisches Verhalten mikrobieller Enzyme unter Druckeinwirkung Eberhard Nürnberg und Stefan Scheler Lehrstuhl für Pharmazeutische Technologie der Friedrich-Alexander-Universität Erlangen-Nürnberg Compression and Disintegration Properties of Tablets Containing Digestive Enzymes of Microbial Origin / 1st Communication: Physicochemical behaviour of microbial enzymes under compression Compression of powder mixtures with a high content of protein - e. g. enzymes for the therapy of exocrine pancreatic insufficiency - is not unproblematic with regard to a short disintegration time as well as a minimized loss of activity. Informations about deformation characteristics and pressure-induced loss of activity are indispensable requirements for an effective formulation of compressed tablets. The activity of the tested Rhizopus lipase decreases less than 5 % on conditions which provide tablets with a high strength (applied pressure: 200 MPa). The measurement of plasticity shows that there is a correlation between the decrease of activity, induced by application of pressure, and the ductility of the material. Key words Aspergillus-Amylase · Aspergillus-Protease · Lipolytische Aktivität · Natriumcaseinat · Pankreatin · Plastizität · Rhizopus-Lipase · Tablettierung · Verdauungsenzyme |
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pharmind 2000, Nr. 8, Seite 630