Online-Kontrolle der Partikelgröße während einer Wirbelschichtgranulation
Untersuchung einer neuartigen Lasersonde zur besseren Kontrolle des Partikelgrößenwachstums in der Wirbelschichtgranulation
Sebastian Schmidt-Lehr1, Hans-Ulrich Moritz1 und Kai C. Jürgens2
Universität Hamburg, Institut für Technische und Makromolekulare Chemie1, Hamburg, und Schering AG2, Berlin
Korrenspondenz: Dipl.-Chem. Sebastian Schmidt-Lehr, Universität Hamburg, Institut für Technische und Makromolekulare Chemie, Bundesstr. 45, 20146 Hamburg (Germany), e-mail: sebastian.schmidt-lehr@chemie.uni-hamburg.de Online-control of the Particle Size during Fluid-bed Granulation / Evaluation of a novel Laser probe for a better control of particle size in fluid-bed granulation
A good control over the particle size distribution during granulation is useful to obtain press masses that exhibit good compressability. Time and resources can be saved using an on-line method capable to determine the particle size in real time thus ensuring the quality of the product and enabling the operator to react to deviations during the manufacturing process. Such a method based on the novel laser probe will be introduced. It will be demonstrated in this article that the granule build up can be followed with high time resolution and in real time. Based on the results obtained with the new probe it was possible to establish a model describing the correlation between the fluid-bed parameters like inlet air temperature, inlet air flow and spray rate and the final particle size in the granulation. With this model it is possible to calculate the parameters settings necessary to obtain a target particle size. Key words Partikelgröße, Größenmessung, Online-Kontrolle, Wachstum • Wirbelschichtgranulation |
