Pectin-Hydroxypropylmethylcellulose Drug Delivery System for Colon TargetingDesign and in vitro evaluation Murat Turkoglu a , Sevgi Takka b , Habip Baran a , and Adel Sakr b Marmara University, Faculty of Pharmacy, Department of Pharmaceutical Technology a , Haydarpasa-Istanbul (Turkey), and University of Cincinnati, College of Pharmacy, Industrial Pharmcy Program b , Cincinnati, Ohio (USA)Pectin-Hydroxypropylmethylcellulose (HPMC) matrix tablets were prepared and evaluated of their dissolution/ erosion properties to assess their colon targeting possibility based on a gastrointestinal transit time concept. Dosage forms were tested in water and also separately in 0.1 N HCl and pH 6.8 buffer systems. HPMCs of three different molecular weights were incorporated as 25 % into a pectin USP matrix in addition to pure pectin tablets. The effect of a pectin-degrading enzyme (Pectinex 3XL) on dissolution rate was also studied. It was found that dissolution/erosion rates were faster in water than in buffer solutions. The t50 values were 3, 3.4, 5.0, and 6.0 h in water and 4.6, 5.3, 9.7, and 11.7 h in a buffer system dependent on the viscosity grade of HPMC. Addition of 25 % HPMC improved the mechanical properties of pectin matrix. Pectinex 3XL accelerated the degradation of pectin tablets as well as HPMC content of matrix. Pectin-HPMC system is recommended as protective wall layers to protect and carry protein drugs to the colon for targeting. Key words Colon targeting · Drug targeting · Hydroxypropylmethylcellulose · Pectin · Pectinase · Tablets, dissolution, erosion |
| © ECV- Editio Cantor Verlag (Germany) 1999 |
pharmind 1999, Nr. 7, Seite 662
