Scale Up der Granulation im Schnellmischer
Gerd Franke und Klaus-JÃ¼rgen Steffens
Pharmazeutische Technologie, Pharmazeutisches Institut der Rheinischen Friedrich-Wilhelms-UniversitÃ¤t Bonn
Scale-up of Granulation in High Shear Mixers
The transition of single production steps of pharmaceutical solid dosage forms from the development scale into industrial production scale very often requires a great amount of time and financial input within the technological development process. The enlargement of batch sizes by a great figure very often leads to unexpected results. For wet granulation in modern high shear mixers a precise measurement of the torque can be the basis for an optimized and time saving scaling up. Within the now completed study it is shown, that a detailed investigation of the measured torque performances can lead to a secure forecast of the granulation quality that is to be expected, while the actual granulation process is still ongoing. The division of torque, as a model, into mixing and agglomeration part, serves a supporting figure, which can be used as a comparison between pilot and production scale.
Key words Drehmomentmessung Â· Granulation Â· Scale Up Â· Schnellmischer
Â© ECV- Editio Cantor Verlag (Germany) 1999
pharmind 1999, Nr. 9, Seite 861