Concepts, Processes and Quality Assurance
Many new active pharmaceutical substances suffer from low solubility in water, and subsequently have a poor bioavailability. These molecules need an enhancement of their solubility to ensure an effective treatment for the patients.
In parallel, some generic companies add value to known molecules by increasing their solubility, and thus bioavailability.
Solid Dispersion (SD) with monographed excipients can be a way to achieve those two goals in a quite easy, reproducible and stable manner.
AQOAT, in some cases also HP and HPMC, open up a streamlined way to formulate solid dispersion preparations (...)