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Statistical Evaluation of Hydroxypropyl Methylcellulose Influence on Drug Release Pattern of a Gastro retentive Floating Drug Delivery System

Bijay K. Sahoo¹, Veeran Gowda², Animesh Ghosh¹, Bappaditya Chattarjee¹, Anirban Bose¹, Uday Chakraborty¹, Ayan Das¹, Tapan K. Pal¹

¹ Department of pharmaceutical Technology, Jadavpur university, Kolkata (India)
² Department of Pharmaceutics, Royal College of Surgeons, Dublin (Ireland)

Corresponding author: Prof. Dr. Tapan K. Pal, Director, Bioequivalence Study Centre, Department of Pharmaceutical Technology, Jadavpur University, Kolkata-700 032 (India), Fax +91-033 24 14 61 86, e-mail: tkpal12@gmail.com

In the present investigation, controlled release gastro retentive floating drug delivery system of ranitidine HCl was developed by employing response surface methodology. A 3² randomized full factorial design was developed to study the effect of formulation variables like various viscosity grades and contents of hydroxypropyl methylcellulose (HPMC) and their interactions on response variables. Tablets were prepared using direct compression technique. The floating lag time for all nine experimental trials batches were less than 5 min and floatation time of more than 12 h. Ranitidine HCl release from the polymeric matrix system followed non-Fickian anomalous transport. Multiple regression analysis revealed that both viscosity and content of HPMC had statistically significant influence on all dependent variables but the effect of these variables found to be non-linear above certain threshold values.

Key words Factorial design • Floating systems • Gastro retentive drug delivery systems, lag floating time • Hydroxypropyl methylcellulose