Transferable Basic Library for the Identification of Active Substances using Near-Infrared SpectroscopyMichel Ulmschneider a , Gabriele Barth a, 1 , Barbara Reder b, 2 , Antonia Vögel b, 3 , and Doris Schilling b, 4 F. Hoffmann-La Roche Ltd., Pharmaceutical Quality Control a , Basel (Switzerland), and Bühler AG ANATEC b , Uzwil (Switzerland) Eine übertragbare Bibliothek für die Identifikation von pharmazeutischen Aktivstoffen mittels Nah-Infrarot-Spektroskopie In this study a method combining near-infrared spectroscopy (NIR) and the corresponding chemometric calibrations was developed for the non-invasive identification of 9 pharmaceutical active substances in sealed glass vials. Almost no sample preparation or cleaning operation is required apart from the filling of the substances into the vials. Measurements were performed directly through the bottom of the glass containers using a horizontal sample desk accessory on 3 similar Fourier-Transform (FT)-NIR spectrometers. This NIR-application can be transferred to any spectrometer of the same type. Key words Chemometric methods · Near infrared spectroscopy · Pharmaceutically active substances, identification · Raw materials · Spectroscopic library, transferability
|
pharmind 2000, Nr. 4, Seite 301
