A new brittle tableting excipient for direct compression and dry granulation with enormous hardness yield
Key Words: Tricalcium citrate, material characterization, direct compression, dry granulation, compression analysis, roller compaction, tabletability
Karl G. Wagner, Department of Pharmaceutical Technology and Biopharmaceutics, University of Bonn, Gerhard-Domagk-Str. 3, 53121 Bonn, Germany; e-mail: firstname.lastname@example.org
Objectives: Tricalcium citrate (TCC) was characterized as a tableting excipient for direct compression (DC) and dry granulation (DG).
Significance: Brittle materials usually lead to tablets of inferior mechanical strength compared to plastic (...)