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Ultrafiltration als eine Möglichkeit der Herstellung von pyrogenfreiem Wasser

Andy Feigenwinter a und Peter Wirz b

Verkauf KSA International (Kundenspezifische Anlagen)a und Verfahrenstechnik Pharma b , Christ AG, Aesch (Schweiz)

Ultrafiltration as Alternative Production Process for Pyrogen-free Water

Up to a few years ago sterile and apyrogenic water could only be produced by distillation. A process is now available which is as reliable as distillation but offers the additional advantage of being much more economical. In principle the reverse osmosis technique also presents an alternative with its lower nominal cut-off in comparison to the ultrafiltration. But since the passage of some germs cannot be excluded even with this system configuration with absolute reliability the subsequent distribution system must in any case - if it is not operated hot - kept free from germs by addition of ozone. For cleaning the membranes, and not because the sterility of the filtrate would not be ensured, the UF plants are steamed with saturated steam at 121 °C in regular intervals. The objective for the application of ultrafiltration plants is in the first instance the economical production of large quantities of water of WFI quality for all kinds of rinsing purposes. Already from small capacities of 500/h on, the ultrafiltration is an extremely economical process and a reliable alternative to the classic distillation.

Key words Destillation · Membranfiltration · Pyrogenfreies Wasser · Steriles Wasser · Ultrafiltration · Umkehrosmose