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In this study, sustained-release tablets of a high loading-dose drug were prepared using small concentrations of dissolution retardant materials. Accordingly, paracetamol was selected as a model of high loading-dose drugs to prepare sustained-release tablets using binary or ternary mixtures of magnesium stearate (Ms), talc (T) and colloidal silica (Aerosil-200^®, Ar).
The results obtained revealed that 6 % w/w of either binary or ternary mixtures of Ms, T and Ar in different ratios produced tablets of good mechanical properties and excellent sustained-release characteristics. In addition, tablets prepared with Ms-T binary mixtures in all of the selected ratios, besides tablets prepared with Ms-Ar binary mixtures in ratios of 3 : 1 and 4: 1 and tablets prepared with Ms-T-Arternary mixtures in ratios of 2 : 2: 1 and 3 : 1 : 1 provided zero-order release kinetics. However, for the remaining patches of tablets containing Ms-Ar binary mixtures (1 : 1 and 2: 1) or Ms-T-Ar ternary mixtures (1 : 1 : 1 and 2: 1: 1), the best fitting was obtained with first-order or Higuchi models.