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    Merken
    Figure 1: HMC takes place in a fluid bed coater under controlled environmental conditions. The melting device (1) contains a heated tank for the molten coating materials, a stirrer and a heated tubing system to avoid solidification during transport of the molten mass into the fluid bed. The air layer gliding process (2) moves the particles into the spraying zone, creating a homogeneous temperature distribution as well as a spiral air circulation. The liquid is sprayed through a heated nozzle (3) and is atomized by compressed air into fine droplets ensuring a precise coating. The dust filter system (4) works continuously during the process. The filter bags, of which there are several, are cleaned by blowing air through the filters, thus removing any dust stuck to them. This approach reduces downtime to a minimum (Image courtesy of INNOJET Herbert Hüttlin).

    Hot Melt Coating for Controlling the Stability, Release Properties and Taste of Solid Oral Dosage Forms

    Verfahrenstechnik

    1. Introduction2. The need for new coating methods3. The hot melt coating process4. Optimizing HMC during formulation5. Scale-up6. Hot melt coating of novel and traditional dosage forms7. Conclusion

    Summary

    Traditional methods to coat solid oral dosage forms mostly use solvents, an approach that suffers from a range of drawbacks including cost, environmental concerns and lengthy processing times. Hot melt coating (HMC) is an innovative and effective alternative that is reliable, cheap and fast, while simultaneously offering an opportunity to better manipulate and control characteristics such as taste, stability and release rate. Here, we discuss the need for HMC, provide technical details of the process including the excipients involved, explore the relative merits and drawbacks of the technology and touch upon how the process can be scaled up ready for commercial production. In particular, we focus on using HMC to coat user-friendly dosage forms such as orally disintegrating granules (ODGs) and the constituents of traditional dosage forms such as hard gelatine capsules and tablets. In each case, HMC enables the development of medicines with fast or extended release profiles, improved stability and longer product shelf life. In the case of ODGs, palatability and ease of swallowing can be improved resulting in higher compliance.

    Dr. Detlev Haack · Hermes Arzneimittel GmbH – Division HERMES PHARMA, Pullach
    Dr. Martin Koeberle · Hermes Arzneimittel GmbH – Division HERMES PHARMA, Pullach

    Correspondence:

    Dr. Detlev Haack, Hermes Arzneimittel GmbH – Division Hermes Pharma, Georg-Kalb-Str. 5-8, 82049 Pullach, Germany

    Summary

    Traditional methods to coat solid oral dosage forms mostly use solvents, an approach that suffers from a range of drawbacks including cost, environmental concerns and lengthy processing times. Hot melt coating (HMC) is an innovative and effective alternative that is reliable, cheap and fast, while simultaneously offering an opportunity to better manipulate and control

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