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Sie suchen in allen Bereichen nach dem Autor Zuccato D.
In der Rubrik Zeitschriften haben wir 2 Beiträge für Sie gefunden
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MerkenExtractables profile of inner-coated containers for pharmaceutical use
Rubrik: Originale
(Treffer aus pharmind, Nr. 04, Seite 382 (2023))
Zuccato D | Rudigier-Voigt E | Löber D
Extractables profile of inner-coated containers for pharmaceutical use / Zuccato et al. • Inner-coated containers · Zuccato D1, Rudigier-Voigt E2, Löber D1 · 1SCHOTT Pharma AG & Co. KGaA, Mainz (Germany) und SCHOTT AG, Mainz (Germany)
Borosilicate glass Cyclic Olefin Polymers Coated vial Alkaline solution Extractables Advanced characterization Oxygen transmission rate The interaction between drug solution and primary packaging containers should be reduced to a minimum extent [ 4 ] during the entire drug product’s shelf life. Leaching of glass elements can trigger adverse effects such as protein aggregation or drug inactivation that may compromise the treatment efficacy and, therefore, become a significant source of risk especially for highly sensitive biologics [ 5 ]. For this reason, the chemical resistance of the primary packaging represents one of its most relevant properties. Thanks to its high chemical ...
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MerkenEffective Alternatives for Ammonium Sulfate Treated Pharmaceutical Glass Vials
Rubrik: Technik
(Treffer aus pharmind, Nr. 01, Seite 139 (2021))
Crawford A | Zuccato D | Hladik B
Effective Alternatives for Ammonium Sulfate Treated Pharmaceutical Glass Vials / Crawford et al. • Alternatives for Ammonium Sulfate Treated Glass Vials · Crawford A, Zuccato D, Hladik B · SCHOTT Pharmaceutical Systems, Lebanon, PA (USA)
Alkali-borosilicate glass has been the material of choice for pharmaceutical primary packaging over the course of decades [ 1 ]. This is due to its technical characteristics, such as its chemical durability, optical transparency, thermal expansion, and mechanical strength, as well as business considerations of speed and cost of manufacture along with raw material availability. These features allow alkali-borosilicate glass to fulfill the requirements to contain a plethora of drug materials in a safe, reliable, and effective manner [ 1 – 4 ]. While originally soda-lime-silicates were the first glass containers produced to store valuable substances, early scientific endeavors found ...
