Quality of herbal medicinal products

Rubrik: Analytik

(Treffer aus pharmind, Nr. 05, Seite 390 (2026))

Goerke T | Halbsguth C | Gehlen-Breitbach S | Schönherr R | Albert H | Onken M | Kolkmann R | Symma N

Quality of herbal medicinal products / Difficulties in the interpretation of fingerprint chromatograms – Part 4*Part 1, 2 and 3 see Pharm. Ind. 2025;87(11):1049–1054,, Pharm. Ind. 2026;88(1):54–59 and Pharm. Ind. 2026;88(3):230–237. · Goerke T, Halbsguth C, Gehlen-Breitbach S, Schönherr R, Albert H, Onken M, Kolkmann R, Symma N · , MCM Klosterfrau Vertriebsgesellschaft und Max Zeller Söhne und Bayer Consumer Health, Steigerwald Arzneimittelwerk und Merz Consumer Care und Salus Haus und Pharmazeutische Fabrik Evers und Diapharm und Pharma Deutschland
Fingerprint Chromatograms GC Herbal Medicinal Products Stability Quality Gas chromatography (GC) is applicable for components that must be gaseous or vaporisable without decomposition. Using a fused silica column, it is the chromatographic technique with the highest separation efficiency, that enables the detection of smallest differences in the GC fingerprints. Therefore, it is particularly useful for the analysis of essential oils. Accordingly, as with the other high-resolution chromatography systems, even the smallest changes in the chromatogram become visible and must be assessed with regard to their relevance. Three months before the expiry date of a batch of an herbal medicinal product, ...

Quality of herbal medicinal products

Rubrik: Analytik

(Treffer aus pharmind, Nr. 03, Seite 230 (2026))

Goerke T | Halbsguth C | Gehlen-Breitbach S | Schönherr R | Albert H | Onken M | Kolkmann R | Symma N

Quality of herbal medicinal products / Difficulties in the interpretation of fingerprint chromatograms – Part 3*Part 1 and 2 see Pharm. Ind. 2025;87(11):1049–11054 and Pharm. Ind. 2026;88(1):54–59. · Goerke T, Halbsguth C, Gehlen-Breitbach S, Schönherr R, Albert H, Onken M, Kolkmann R, Symma N · , MCM Klosterfrau Vertriebsgesellschaft und Max Zeller Söhne und Bayer Consumer Health, Steigerwald Arzneimittelwerk und Merz Consumer Care und Salus Haus und Pharmazeutische Fabrik Evers und Diapharm und Pharma Deutschland
Fingerprint HPLC Structural Changes Michael Addition Isomerisation The following 3 examples are used to describe variabilities in high performance liquid chromatography (HPLC) fingerprint chromatograms that are not due to methodological reasons but can be attributed to structural changes (e.g. isomerization, rearrangements or other chemical changes) of certain plant constituents. It is often difficult to assess whether these structures were already genuinely present in the plant material or must be regarded as artefacts that arise during the production/storage of the extracts/tinctures and/or finished dosage forms. Such differentiation is crucial for assessing whether these changes represent quality-relevant deviations or can be regarded as ...

Quality of herbal medicinal products

Rubrik: Analytik

(Treffer aus pharmind, Nr. 01, Seite 54 (2026))

Goerke T | Halbsguth C | Gehlen-Breitbach S | Schönherr R | Albert H | Onken M | Kolkmann R | Symma N

Quality of herbal medicinal products / Difficulties in the interpretation of fingerprint chromatograms – Part 2*Part 1 see Pharm. Ind. 2025;87(11):1049–1054. · Goerke T, Halbsguth C, Gehlen-Breitbach S, Schönherr R, Albert H, Onken M, Kolkmann R, Symma N · MCM Klosterfrau Vertriebsgesellschaft und Max Zeller Söhne und Bayer Consumer Health, Steigerwald Arzneimittelwerk und Merz Consumer Care und Salus Haus und Pharmazeutische Fabrik Evers und Diapharm und Pharma Deutschland
Fingerprint Chromatograms HPLC Column Batches Laboratories Peak Separation Due to its high precision and specificity, high-performance liquid chromatography (HPLC) is very common in the analysis of herbal active ingredients and has increasingly replaced the earlier photometric methods. High-performance liquid chromatography is a widely used analytical technique, particularly for determining the content of active plant substances in the finished product. In addition to analysing the analytical marker for batch-specific recovery, HPLC fingerprints are also used to assess quality. The high selectivity of HPLC especially when using modern column materials, and high sensitivity of the different detectors, mean that minor changes are ...