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Sie suchen in allen Bereichen nach dem Autor Okunola O.
In der Rubrik Zeitschriften haben wir 2 Beiträge für Sie gefunden
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MerkenNovel Stealth Nanoparticles Prepared by Dispersion Polymerization
Rubrik: Originale
(Treffer aus pharmind, Nr. 08, Seite 1346 (2013))
Novel Stealth Nanoparticles Prepared by Dispersion Polymerization / Novel stealth degradable nanoparticles prepared by dispersion polymerization for the delivery of bioactive agentsPart II*Part I see Pharm. Ind. 2013:75(7)1191-1196 · Akala E, Okunola O · Department of Pharmaceutical Sciences/Center for Drug Research and Development (CDRD), College of Pharmacy, Howard University, Washington, DC, USA
Scheme 1 shows the synthesis of the hydrolyzable crosslinked PEG-PMMA nanoparticles. The synthesis of the polymeric nanoparticles proceeded by the free radical dispersion polymerization of a hydrophilic macromonomer (poly(ethylene glycol) monomethyl ether monomethacrylate (PEG-MA)) and a hydrophobic comonomer (MMA) in a binary solvent system (ethanol:water). The mechanism for the formation of polymeric nanoparticles synthesized by dispersion polymerization involving macromonomer technique has been reported [ 18 , 19 ], and is believed to proceed in two major stages: (a) nuclei formation and (b) nuclei growth. At the start of the process, MMA, PEG-MA, crosslinker (XL) and initiator formed a homogeneous solution. ...
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MerkenNovel Stealth Nanoparticles Prepared by Dispersion Polymerization
Rubrik: Originale
(Treffer aus pharmind, Nr. 07, Seite 1191 (2013))
Novel Stealth Nanoparticles Prepared by Dispersion Polymerization / Novel stealth degradable nanoparticles prepared by dispersion polymerization for the delivery of bioactive agentsPart I · Akala E, Okunola O · Department of Pharmaceutical Sciences/Center for Drug Research and Development (CDRD), College of Pharmacy, Howard University, Washington, DC, USA
Controlled drug release Dispersion polymerization Nanoparticles Paclitaxel Redox initiator One of the great challenges in drug development and medicine today is finding more effective forms of treatment for a large number of life-threatening but curable diseases such as cancer. Efforts are being made to better understand cancer biology and to design effective and tumor cell-selective therapies; however, new approaches to cancer research and chemotherapeutic drug development need to be developed [ 1 , 2 ]. At the moment, there is an imbalance between the knowledge of cancer biology and the success achieved in cancer treatment: efforts in the treatment of ...
