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    Rubrik: Technik

    Microliter Dosing with Prefillable Syringes

    Prefilled Lucentis © makes for an interesting case study as it is indicated at different strengths for Age-related Macular Degeneration (AMD, 0.5 mg) and Diabetic Macular Edema (DME, 0.3 mg). The 0.5 mg Lucentis © is a 50 μl dose volume. Rather than deliver a 30 μl dose volume for the 0.3 mg, Lucentis © was reformulated to deliver 0.3 mg in a 50 μl dose. Data has been published showing overlap between a 30 μl and 50 μl dose using a 1 ml tuberculin syringe (equivalent internal diameter to a 0.5 ml Prefilled syringe (PFS)). This overlap encapsulates the challenge where the syringe is operating at the limits of human capability ...