Header
 
Login
 

Privatsphäre-Einstellungen

Wir verwenden Cookies auf unserer Website. Einige von ihnen sind unerlässlich, während andere uns helfen, diese Website und Ihre Erfahrungen zu verbessern.

Notwendig Statistik Marketing
Auswahl bestätigen
Weitere Einstellungen

Hier finden Sie eine Übersicht aller verwendeten Cookies. Sie können ganzen Kategorien Ihre Zustimmung geben oder weitere Informationen anzeigen und bestimmte Cookies auswählen.

Alle auswählen
Auswahl bestätigen
Notwendig Cookies
Wesentliche Cookies ermöglichen grundlegende Funktionen und sind für die ordnungsgemäße Funktion der Website erforderlich.
Statistik Cookies
Statistik-Cookies sammeln anonym Informationen. Diese Informationen helfen uns zu verstehen, wie unsere Besucher unsere Website nutzen.
Marketing Cookies
Marketing-Cookies werden von Werbekunden oder Publishern von Drittanbietern verwendet, um personalisierte Anzeigen zu schalten. Sie tun dies, indem sie Besucher über Websites hinweg verfolgen
Zurück

    Release of Glucocorticoids from Ethylcellulose Latex Formulations Prepared as Drug-carrier Complexes and with Microencapsulation

    Maria Adolfina Ruiz, Maria Encarnacion Morales, Maria Ester Garcia, and Visitacion Gallardo

    Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Granada, Granada (Spain)

    Correspondence: Dr. M. A. Ruiz, Dept. Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Granada, 18071 Granada (Spain), Fax +3458248958, e-mail: adolfina@ugr.es

    The aim of this study was to compare formulations for the modified release of active principles from latex carriers, in which the drug was incorporated by adsorption or microencapsulation. To determine their influence on adsorption and microencapsulation, two glucocorticoids differing in physicochemical properties were tested: water-soluble methylprednisolone sodium hemisuccinate and lipo-soluble budesonide. Ethylcellulose latex was synthesized with the method proposed by Vanderhof and colleagues (latex L), and its particle shape and size were compared with a commercially available latex of similar composition (Aquacoat®). Release studies were done with the method of Mena and colleagues. Assays to quantify adsorption showed that Aquacoat, because of its smaller particle size, adsorbed more of the drug than latex L. To obtain information on how to optimize the production of drug-carrier complexes, adsorption of both drugs on both types of latex was studied under different pH, time and concentration conditions. Adsorption was maximal after about 4 h at pH 5- 6. The two active principles were combined with the latex carrier by encapsulation during synthesis, and drug release was compared in formulations to which PEG or silicone excipients was added. Microencapsulation efficiency ranged from 84 % to 90 % for both active principles. Drug release was greater with the hydrophilic excipient than with the silicone-based excipient. The data showed that encapsulation prolonged the effect of the drug by slowing release. The formulation with PEG excipient yielded the best release values.

    Key words Corticoids • Controlled release • Ethylcellulose latex




    © ECV- Editio Cantor Verlag (Germany) 2006

     

    pharmind 2006, Nr. 2, Seite 234