| Significance of Capillary Electrophoresis in the Pharmaceutical Industry Ulrike Holzgrabe Institute of Pharmacy and Food Chemistry, University of Würzburg, Würzburg (Germany) Capillary electrophoresis (CE) and related techniques are well established methods in many analytic fields, especially in the case of the separation of biomolecules, e.g. of DNA. Even though CE can be a rather good alternative to high performance liquid chromatography (HPLC) for the evaluation of drug quality it is rarely applied. This is due to the reservation of national licensing authorities and pharmacopoeia commissions for some reason such as lack of reproducibility and sensitivity. The following paper wants to demonstrate that the aforementioned draw-backs are often no longer true. On the other hand several examples are given which clearly prove that CE can be superior to HPLC and, thus, should be more often considered in drug quality control. Key words Capillary electrophorersis • Drug quality control • Micellar electrokinetic capillary chromatography |
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pharmind 2005, Nr. 10, Seite 1209
