Harnessing the Potential of MicroRNAs to Enhance Performance of Biopharmaceutical Production Cell Factories

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(Treffer aus pharmind, Nr. 12, Seite 1760 (2016))

Fischer S | Handrick R | Otte K

Harnessing the Potential of MicroRNAs to Enhance Performance of Biopharmaceutical Production Cell Factories / Fischer et al. • Potential of MicroRNAs · Fischer S, Handrick R, Otte K · ¹Institute of Applied Biotechnology, University of Applied Biotechnology, Biberach an der Riß, Germany und ²BP Process Development Germany, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riß, Germany
Biopharmaceuticals microRNAs Chinese hamster ovary (CHO) cells Monoclonal antibodies Cell engineering Process development Biopharmaceuticals (or biologics) are complex macromolecular drugs that are used for treatment of severe disorders such as cancer, diabetes, immunological, ophthalmic or neurodegenerative diseases. As the demand for biologicals is still steadily increasing there is also a requirement to develop cost-effective and more efficient manufacturing processes. Biopharmaceuticals mostly comprise products which are generated by means of recombinant DNA technology such as peptides, proteins, nucleic acids, vaccines or viral vectors used for gene and oncolytic therapy. The first therapeutic protein approved in 1987 by the US Food and ...