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Sie suchen in allen Bereichen nach dem Autor Islambulchilar Z.
In der Rubrik Zeitschriften haben wir 1 Beitrag für Sie gefunden
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MerkenSolubilization of Sirolimus Using SNEDDS Formulations
Rubrik: Originale
(Treffer aus pharmind, Nr. 04, Seite 562 (2015))
Islambulchilar Z | Valizadeh H | Zakeri-Milani P
Solubilization of Sirolimus Using SNEDDS Formulations / Application of Statistical Experimental Design · Islambulchilar Z, Valizadeh H, Zakeri-Milani P · 1 Student Research Committee and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran und 2 School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran und 3 Drug Applied Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran und 4 Liver and Gastrointestinal Diseases Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
Dissolution Sirolimus SNEDDS Solubility Solubilization Statistical design Solubility and hence dissolution behavior of drug compounds besides their permeability are critical aspects for their oral bioavailability [ 1 ]. Since a large number of drug candidates are lipophillic in nature and have poor aqueous solubility, solubilization of these poorly soluble drugs presents a major and frequently encountered challenge in the formulation design and development as well as a potential hurdle in their oral delivery [ 2 ]. Numerous formulation approaches have been used to overcome these problems including use of prodrugs, crystal polymorph selection, solid dispersions, inclusion complexes with beta-cyclodextrins, nanoparticles, ...
