Rubrik: Verfahrenstechnik
(Treffer aus TechnoPharm, Nr. 05, Seite 258 (2014))
Haack D | Koeberle M
Hot Melt Coating for Controlling the Stability, Release Properties and Taste of Solid Oral Dosage Forms / Haack und Koeberle – Hot Melt Coating · Haack D, Koeberle M · Hermes Arzneimittel GmbH – Division HERMES PHARMA, Pullach und Hermes Arzneimittel GmbH – Division HERMES PHARMA, Pullach
Pharmaceuticals and food supplements are often administered via the oral route, as it is the cheapest, simplest and safest approach available. However, many APIs must be effectively coated during the formulation process in order to successfully exert its functional effects after swallowing. There can be several reasons for this. For instance, many APIs are sensitive to environmental factors such as oxygen, light and humidity, the likes of which can lead to degradation. The internal microenvironment within the dosage form can also be important, with acidic, alkaline or functional excipients often causing API instability. Solid oral dosage forms must also display ...