(Treffer aus pharmind, Nr. 11, Seite 1714 (2014))
Ettner N | Meyer E
IP Strategies in the Generics and Pharmaceutical Industries / Between branded drug life cycle management and innovative generics (Part 2)*Teil 1 s. Pharm. Ind. 2014;76(10):1548–1553 · Ettner N, Meyer E · 1
Kandern-Wollbach (Germany) und 2
In 1989, Pfizer´s UK-based research site in Sandwich synthesized sildenafil at first, resulting in British patent application (GB9013750) entitled “Pyrazolopyrimidinone antianginal agents” (filed on June 20, 1990 [ 39 , 40 , 41 ]). A European patent application was subsequently filed on June 7, 1991 (EP0463756). The corresponding US patent application US5,25,0534 is listed in the Orange Book of the FDA. The patent claims a series of pyrazolo[4,3-d]pyrimidin-7-one compounds as potent and selective inhibitors of 5 cyclic guanosine 3´,5´-monophosphate phosphodiesterase (cGMP PDE5). In 1991, British priority application GB9126260 specified sildenafil for the use as heart medicine (see Fig. 3 , number 2); the ...