Rubrik: Applikationssysteme
(Treffer aus TechnoPharm, Nr. 05, Seite 276 (2014))
Wanke C | Shimizu J
IntelliCap / A pharmaceutical research and development tool for modified release development · Wanke C, Shimizu J · Medimetrics Personalized Drug Delivery B.V., AE Eindhoven, The Netherlands und Medimetrics Personalized Drug Delivery Inc., Briarcliff Manor, NY, USA
Modified Release Drug Absorption Drug Development Drug Device Combination Oral delivery is by far the most convenient and preferred means to administer a medication. Development of an oral product typically starts with an immediate release formulation representing the most frequent and preferred development route. Whenever an oral immediate release formulation does not meet pharmacokinetic (e. g. C max related toxicity), regional delivery (e. g. drug substance is not stable under the acidic conditions in the stomach), or administration frequency requirements (e. g. short half-life), the development of a modified release formulation has to be considered. In addition, developing a modified release formulation may ...