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Sie suchen in allen Bereichen nach dem Autor Wibel R.
In der Rubrik Zeitschriften haben wir 2 Beiträge für Sie gefunden
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MerkenNatural and Synthetic Phospholipids
Rubrik: Technik
(Treffer aus pharmind, Nr. 07, Seite 668 (2024))
Wibel R | van Hoogevest P | Hölig P
Natural and Synthetic Phospholipids / For Vaccines and Other Complex Drug Delivery Systems – Part 2*Part 1 of this article see Pharm. Ind. 2024;86(6):555–563. · Wibel R, van Hoogevest P, Hölig P · Lipoid und PHARMANOVATION Consulting und Lipoid
Phospholipids Vaccines Depot injectables Pulmonary dosage forms Parenteral (mainly i.m. or subcutaneous, s.c.) depot injections are of interest to reduce the administration frequency and increase patient compliance for potent drugs. In addition, the steady and slow drug release prevents high C max values with concomitant side effects. Phospholipids play a prominent role in parenteral depot formulations. Whereas polymer-based depot formulations are used for drug release periods of up to several months, lipid-based systems are more suitable for drug release periods up to one week. Liposomes possess an aqueous compartment from which water-soluble drugs can slowly diffuse through the phospholipid membrane ...
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MerkenNatural and Synthetic Phospholipids
Rubrik: Übersichten
(Treffer aus pharmind, Nr. 06, Seite 555 (2024))
Wibel R | van Hoogevest P | Hölig P
Natural and Synthetic Phospholipids / For Vaccines and Other Complex Drug Delivery Systems – Part 1 · Wibel R1, van Hoogevest P2, Hölig P1 · 1Lipoid GmbH, Ludwigshafen am Rhein und PHARMANOVATION Consulting, Rheinfelden (Baden)
Phospholipids Vaccines Depot injectables Pulmonary dosage forms All lipids that contain phosphorus are called phospholipids. Phospholipids are surface-active, amphiphilic molecules, which comprise a polar headgroup and a lipophilic tail. They can be found in any cell membrane and are therefore intrinsically biocompatible and biodegradable. The phospholipid molecule comprises a glycerol backbone, which is esterified in positions 1 and 2 with fatty acids and in position 3 with phosphate ( fig. 1 ). The systematic designation of, e.g. , phosphatidic acid (PA) is 1,2-diacyl- sn -glycero-3-phosphate (where sn means stereospecific numbering). The sn -2 carbon atom of glycerophospholipids is a chiral center, and natural ...
