Modeling and Control of a Continuous Vibrated Fluidized Bed Dryer in Pharmaceutical Tablets Production

Rubrik: Originale

(Treffer aus pharmind, Nr. 12, Seite 1693 (2019))

Elkhashap A | Meier R | Abel D

Modeling and Control of a Continuous Vibrated Fluidized Bed Dryer in Pharmaceutical Tablets Production / Elkhashap et al. • Continuous Vibrated Fluidized Bed Dryer · Elkhashap A, Meier R, Abel D · ¹Institut für Regelungstechnik, RWTH Aachen University, Aachen und L. B. Bohle Maschinen + Verfahren GmbH, Ennigerloh
Vibrated fluid bed dryer (VFBD) Nonlinear Model Predictive Controller (NMPC) Wet Granulation and Drying Process Modeling continous pharmaceutical manufacturing The design and control of continuous pharmaceutical manufacturing lines has been a very attractive topic with a huge research potential for the pharmaceutical industry in the last decade. This is due to the great economic benefit and production efficiency presented by the continuous configuration compared to the old classical batch production. Therefore, organizations responsible for monitoring and mentoring the pharmaceutical manufacturers as well as scientific research institutes have been trying to devise a set of concepts (e.g., Quality by Design (QbD) [ ...

Rapid Control Prototyping for Continuous Pharmaceutical Tablet Production Processes

Rubrik: Technik

(Treffer aus pharmind, Nr. 02, Seite 290 (2017))

Groß-Weege C | Rehbaum H | Abel D

Rapid Control Prototyping for Continuous Pharmaceutical Tablet Production Processes / Groß-Weege et al. • Rapid Control Prototyping · Groß-Weege C, Rehbaum H, Abel D · ¹Institut für Regelungstechnik, RWTH Aachen University, Aachen (Germany) und ²L.B. Bohle Maschinen + Verfahren GmbH, Ennigerloh (Germany)
More recently, continuous processes and the idea of continuous production systems have received increased interest in the pharmaceutical industry for solid dosage forms. Batch-oriented production processes – currently state of the art in the pharmaceutical industry – are known to have limited flexibility, higher risks of waste production and reduced capabilities of in-process monitoring. Additionally, regulatory facilities stimulated the pharmaceutical industry by several approaches, including Quality by Design (QbD) and Process Analytical Technology (PAT), to raise its interest in an in-depth understanding of process and product characteristics. To overcome these limitations and implement new quality approaches, integrated continuous production systems ...