Dry powder inhalation of Celecoxib nanoparticles

Rubrik: Originale

(Treffer aus pharmind, Nr. 11, Seite 1652 (2015))

Yaqoubi S | Barzegar-Jalali M | Adibkia K | Hamishehkar H

Dry powder inhalation of Celecoxib nanoparticles / Formulation and in-vitro characterization · Yaqoubi S, Barzegar-Jalali M, Adibkia K, Hamishehkar H · ¹Biotechnology Research Center and Students’ Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran. und ²Research Center for Pharmaceutical Nanotechnology and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran. und ³Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Celecoxib Nanoparticle Dry Powder Inhaler Nanocrystal Pulmonary Drug Delivery DPI Non-small-cell lung cancer (NSCLC) is now the most fatal malignant neoplasm among cancer related morbidity and mortality in both men and women. Improvement of lung cancer survival over the last 30 years has been unsatisfactorily slow [ 1–3 ]. In fact the morbidity ratio caused by lung cancer is now more than the summation of deaths caused by all other types of solid tumors like colorectal, prostate, breast, and pancreatic cancer. And also, the lungs are the main site of metastases from other malignant tissues such as breast, prostate and colon [ 3 ...

Physicochemical characterization of methylprednisolone acetate-PLGA electrosprayed nanoparticles

Rubrik: Originale

(Treffer aus pharmind, Nr. 03, Seite 418 (2015))

Javadzadeh Y | Payab S | Noorizadeh P | Jafari-Aghdam N | Omidfar D | Mohammadi G | Adibkia K

Physicochemical characterization of methylprednisolone acetate-PLGA electrosprayed nanoparticles / Javadzadeh et al. • Physicochemical characterization of methylprednisolone acetate · Javadzadeh Y, Payab S, Noorizadeh P, Jafari-Aghdam N, Omidfar D, Mohammadi G, Adibkia K · ¹Biotechnology Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran und ²Student Research Committee and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran und ³Novel Drug Delivery Research Center, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran und ⁴Drug Applied Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran und
Methylprednisolone acetate PLGA Electrospraying Physicochemical characteristics Release rate In the recent decades, the pharmaceutical industry has been extensively developing thanks to advantages of novel drug delivery systems among which nanoformulations have been investigated and utilized by many researchers due to their decreased side effects and improved efficacy. [ 1 , 2 ] Nanoformulations could be prepared via various methods such as emulsification solvent evaporation, nanoprecipitation, self-assembly, supercritical fluid and electrospinning. [ 3-5 ] Unlike most of the mentioned techniques, which are usually limited to laboratory scale, electrospinning could easily be applied in industrial scale as a result of its simplicity ...

Characterization of Naproxen Solid Dispersions

Rubrik: Originale

(Treffer aus pharmind, Nr. 02, Seite 271 (2015))

Barzegar-Jalali M | Ghanbarzadeh S | Shokri J | Hasanzadeh D | Atapoor N | Sabzevari A | Adibkia K

Characterization of Naproxen Solid Dispersions / Physicochemical characterization of naproxen solid dispersions prepared by a cogrinding method · Barzegar-Jalali M, Ghanbarzadeh S, Shokri J, Hasanzadeh D, Atapoor N, Sabzevari A, Adibkia K · ¹ Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran und ² Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran und ³ Dermatology & Dermopharmacy Research Team, Tabriz University of Medical Sciences, Tabriz, Iran und ⁴ Students Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran und ⁵ Department of pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
Cogrinding Crospovidone Dissolution rate Naproxen Powder of service tree fruit Solid dispersion Veegum Drug absorption from the gastrointestinal tract can be limited by a variety of factors. The most significant contributing factors are poor water solubility and poor membrane permeability of the drug molecules. A drug must be dissolved in water for therapeutic efficacy and the solubility of a drug is a key determinant to its oral bioavailability. Most of the recently introduced drugs are poorly soluble in water [ 1 , 2 ]. When delivering a drug orally, it must first dissolve in gastric or intestinal fluids before it ...