Development of Carrier Free Montelukast Dry Powder Inhalation Formulation

Rubrik: Originale

(Treffer aus pharmind, Nr. 10, Seite 1535 (2015))

Faramarzi P | Haririan I | Ghanbarzadeh S | Yaqoubi S | Hamishehkar H

Development of Carrier Free Montelukast Dry Powder Inhalation Formulation / Faramarzi et al. • Montelukast Dry Powder Inhalation · Faramarzi P, Haririan I, Ghanbarzadeh S, Yaqoubi S, Hamishehkar H · ¹Department of Pharmaceutics, School of Pharmacy, International Campus, Tehran University of Medical Sciences (IC-TUMS), Tehran, Iran und ²Biomaterials Research Center (BRC), Tehran University of Medical Sciences (IC-TUMS), Tehran, Iran und ³Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran und ⁴Department of Pharmaceutics, Faculty of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran und ⁵Biotechnology Research Center and Students’ Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran und ⁶Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Montelukast sodium Dry powder inhaler Spray drying technique Pulmonary drug delivery DPI Asthma is a hypersensitivity disorder of the airways, characterized by chronic inflamed and easily collapsible airways as well as reversible airway obstruction [ 1 ]. Numerous approaches can serve as treatments for this disease, particularly the pulmonary drug delivery route, which represents an appealing and encouraging way to localize treatment of respiratory diseases like asthma [ 2 ]. The main advantages of the pulmonary route compared with other drug administration routes are associated with the large alveolar surface area suitable for drug absorption and extensive vascularization with the relatively low ...

Improved Anticancer Effect of L-778,123, a Farnesyl-transferase Inhibitor

Rubrik: Originale

(Treffer aus pharmind, Nr. 06, Seite 920 (2015))

Ghasemi S | Ghanbarzadeh S | Mozaffari S | Davaran S

Improved Anticancer Effect of L-778,123, a Farnesyl-transferase Inhibitor / Use of PEGylated Fe3O4 Nanoparticles · Ghasemi S, Ghanbarzadeh S, Mozaffari S, Davaran S · ¹Department of Medicinal Chemistry, School of Pharmacy, Guilan University of Medical Sciences, Rasht, Iran und Department of Pharmaceutics, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran und ³Department of Radio Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran und Department of Medicinal Chemistry, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran und Department of Medical Nanotechnology, Faculty of Advanced Medical Science, Tabriz University of Medical Sciences, Tabriz, Iran
Anticancer agent PEGylated Fe 3 O 4 nanoparticles L-778,123 Farnesyl-transferase inhibitor MTT assay Cancer is the second leading cause of death and around the world tremendous resources are being invested in prevention, diagnosis and treatment of cancer. Discovery and development of anticancer agents are the key focus of several pharmaceutical companies. Conventional anticancer drug discovery and development have focused on the cytotoxic agents. The discovery and development of anticancer drugs, especially cytotoxic agents, differ significantly from the drug development process for any other indication [ 1-3 ]. Proteins that transmit abnormal growth signals offer enticing points of intervention for the ...

Surface Modification of Liposomes

Rubrik: Originale

(Treffer aus pharmind, Nr. 05, Seite 748 (2015))

Pourmoazzen Z | Bagheri M | Valizadeh H | Ghanbarzadeh S | Entezami A

Surface Modification of Liposomes / Effects of surface modification of liposomes by linear and cross-linked cholesterol-based anchor polymers on the membrane's phase transition, fluidity and stability · Pourmoazzen Z, Bagheri M, Valizadeh H, Ghanbarzadeh S, Entezami A · ¹Chemistry Department, Science Faculty, Azarbaijan Shahid Madani University, Tabriz, Iran und ²Research Center for Pharmaceutical Nanotechnology and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran und ³Polymer Laboratory, Organic Chemistry Department, Chemistry Faculty, Tabriz University, Tabriz, Iran
Cholesterol Drug delivery Liposome Polyethylene glycol Polymerization Liposomes are self-assembled vesicles consisting of a spherical bilayer structure surrounding an aqueous core domain [ 1 ]. Liposomes showed characteristics such as biocompatibility, biodegradability and low toxicity, where they can be affected by changing size, lipid composition and physical characteristics [ 2 ]. Depending on the preparation procedures, liposome sizes differ in the range of 20 nm to several microns. Small unilamellar liposomes may be produced by high-intensity ultra-sonication or high-pressure homogenization [ 3 , 4 ]. Liposomes have been widely used as drug carriers due to their structural versatility in terms of ...