Determination of thermokinetic and thermodynamic parameters of alprazolam-lactose interaction based on non-isothermal DSC studies

Rubrik: Originale

(Treffer aus pharmind, Nr. 02, Seite 256 (2019))

Ghaderi F | Nemati M | Siahi-Shadbad M | Valizadeh H | Monajjemzadeh F

Determination of thermokinetic and thermodynamic parameters of alprazolam-lactose interaction based on non-isothermal DSC studies / Application to solid state pharmaceutical preparations · Ghaderi F, Nemati M, Siahi-Shadbad M, Valizadeh H, Monajjemzadeh F · ¹Department of Pharmaceutical and Food Control, Urmia University of Medical Sciences, School of Pharmacy, Urmia und Food and Drug Safety Research Center, Tabriz University of Medical Sciences, ( und Department of Pharmaceutical and Food Control, Tabriz University of Medical Sciences, Iran und Drug Applied Research Center, Tabriz University of Medical Sciences, ) und Department of Pharmaceutics, Tabriz University of Medical Sciences und Tabriz und ( und Iran und ) und Tabriz und ( und Iran und ) und Tabriz und ( und Iran und ) und Tabriz und ( und Iran und )
Alprazolam Kinetic Incompatibility DSC Aprazolam is triazolo analog of the benzodiazepine class psychoactive drugs and works by binding to specific sites on the gamma-aminobutyric acid ( GABA ) receptor s. This drug is used to treat anxiety and panic disorders and has other pharmaceutical effects such as sedative , hypnotic , skeletal muscle relaxant and anticonvulsant Alprazolam (8-Chloro-1-methyl-6-phenyl-4 H -[1,2,4]triazolo[4,3-a][1,4]benzodiazepine) is available for oral administration in compressed tablet and extended-release capsule formulations [ 1 , 2 ]. Thermal methods such as differential scanning calorimetry (DSC), differential thermal analysis (DTA) and thermogravimetry (TG) are well-established techniques in assessment ...

Non isothermal decomposition kinetics and compatibility studies of doxepin with sucrose

Rubrik: Originale

(Treffer aus pharmind, Nr. 08, Seite 1222 (2015))

Ghaderi F | Nemati M | Siahi-Shadbad M | Valizadeh H | Monajjemzadeh F

Non isothermal decomposition kinetics and compatibility studies of doxepin with sucrose / Ghaderi et al. • Compatibility Studies · Ghaderi F, Nemati M, Siahi-Shadbad M, Valizadeh H, Monajjemzadeh F · ¹Department of pharmaceutical and Food Control, Tabriz University of Medical Sciences, Tabriz, Iran und ²Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran und ³Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran und ⁴Department of Pharmaceutics , Tabriz University of Medical Sciences, Tabriz, Iran
Doxepin Sucrose Incompatibility Kinetic DSC FTIR The thermal analysis is widely used to describe analytical techniques that elucidate the behavior of chemical substances as a function of temperature. Application of thermal methods is a valuable tool in pharmaceutical sciences in the analysis of the purity, determining the kinetic parameters and drug-excipient interactions. The later may lead to significant changes in the chemical properties, stability, solubility, absorption and therapeutic response of drug molecules [ 1-4 ]. During the development of dosage forms, evaluation of drug-excipient incompatibilities is an important part of the preformulation studies [ 5 ]. Differential scanning calorimetry (DSC) ...

Surface Modification of Liposomes

Rubrik: Originale

(Treffer aus pharmind, Nr. 05, Seite 748 (2015))

Pourmoazzen Z | Bagheri M | Valizadeh H | Ghanbarzadeh S | Entezami A

Surface Modification of Liposomes / Effects of surface modification of liposomes by linear and cross-linked cholesterol-based anchor polymers on the membrane's phase transition, fluidity and stability · Pourmoazzen Z, Bagheri M, Valizadeh H, Ghanbarzadeh S, Entezami A · ¹Chemistry Department, Science Faculty, Azarbaijan Shahid Madani University, Tabriz, Iran und ²Research Center for Pharmaceutical Nanotechnology and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran und ³Polymer Laboratory, Organic Chemistry Department, Chemistry Faculty, Tabriz University, Tabriz, Iran
Cholesterol Drug delivery Liposome Polyethylene glycol Polymerization Liposomes are self-assembled vesicles consisting of a spherical bilayer structure surrounding an aqueous core domain [ 1 ]. Liposomes showed characteristics such as biocompatibility, biodegradability and low toxicity, where they can be affected by changing size, lipid composition and physical characteristics [ 2 ]. Depending on the preparation procedures, liposome sizes differ in the range of 20 nm to several microns. Small unilamellar liposomes may be produced by high-intensity ultra-sonication or high-pressure homogenization [ 3 , 4 ]. Liposomes have been widely used as drug carriers due to their structural versatility in terms of ...