Rubrik: Originale
(Treffer aus pharmind, Nr. 11, Seite 1523 (2021))
Graf A | Neubrand C | Baur D | Kadisch M
Comparison of Raman and MIR spectroscopy for bioprocess monitoring of mammalian cell cultures / Graf et al. • Bioprocess Monitoring · Graf A, Neubrand C, Baur D, Kadisch M · Rentschler Biopharma SE, Laupheim und
CHO cell culture multivariate data analysis (MVDA) process analytical technologies (PAT) raman spectroscopy MIR spectroscopy Quality by Design (QbD) and Process Analytical Technologies (PAT) have been an important topic in the biopharmaceutical industry for some years but have recently witnessed a significant push in implementation in manufacturing [ 1 – 3 ]. While the industry generally has the tendency to be slow in adapting new methodologies, recent technical developments, in combination with the trend towards intensified, high-throughput manufacturing, has helped boosting this quick acceptance in the biopharmaceutical industry. Within the PAT/QbD framework, on-line process monitoring, and control of a design ...