Rubrik: Technik
(Treffer aus pharmind, Nr. 08, Seite 784 (2023))
Aldi S | Lehmann F
Isolator for the CAR-T-Cell Therapy / Aldi and Lehmann • Isolator CAR-T-Cell Therapy · Aldi S, Lehmann F · Allschwil (Switzerland)
Advanced therapy medicinal products (ATMPs) are fast-growing fields in the modern medicine and cell & gene therapies become a hot topic for pharmaceuticals and manufacturing industries. Cell & gene therapies were developed by scientists which improved basic research concepts and protocols to be used for clinical purpose, such as gene manipulations via viral transduction, specific phenotypic cell population isolation, and stem cell differentiation. Methodologies, immunology knowledge, and molecular biology approaches have been notably improved during the past 10 years, by the development of magnetic bead-based systems for phenotypic cell isolation, cancer antigen selection as well as clustered regularly interspaced short palindromic repeats -Cas9 nuclease (CRISPR-Cas9) ...