(Treffer aus pharmind, Nr. 02, Seite 312 (2013))
Hühn E | Langguth P
In Vitro-In Vivo Correlations / General principles and methodologies, regulatory aspects and applications (Part 2)*Part 1 see Pharm. Ind. 2013;75(1):143–152 · Hühn E, Langguth P · Institute of Pharmacy and Biochemistry, Pharmaceutical Technology and Biopharmaceutics, Johannes Gutenberg University, Mainz, Germany
Mass balance methods are the oldest methods to determine the fraction of dose absorbed. They are model dependent, relatively comprehensible and for this reason still frequently used. Mass balance methods are based on the following assumption: Amount of drug absorbed = amount of drug in body + amount of drug eliminated. This means that drug which has been absorbed must either still be in the body or has been eliminated. Wagner-Nelson The Wagner-Nelson method [ 22 ] is suitable for drugs which can be described by the one-compartment model. F t = cumulative fraction of drug absorbed at time ...