Determination of the degree of siliconization on rubber seals for pharmaceutical use by FT-IR spectroscopy

Rubrik: Originale

(Treffer aus pharmind, Nr. 07, Seite 980 (2018))

Moeremans B | Thijs A | Jongen B | Yperman J | Carleer R

Determination of the degree of siliconization on rubber seals for pharmaceutical use by FT-IR spectroscopy / Moeremans et al. • Siliconization on rubber seals · Moeremans B, Thijs A, Jongen B, Yperman J, Carleer R · ¹Institute for Materials Research, Hasselt University, Diepenbeek und Datwyler Pharma Packaging, ( und Research group of Applied and Analytical Chemistry, Hasselt University, Belgium und ) und Alken und ( und Belgium und ) und Diepenbeek und ( und Belgium und )
In the drug industry the demand for efficient seals for pharmaceuticals and biological fluids in vials and syringes is very high. These components (stoppers, plungers etc.) act both as a seal and as a barrier preventing contamination of the pharmaceutical. Manufactured seals using butyl rubber are an excellent solution for this purpose. A limitation of these rubber stoppers is their adherence to each other (twin formation). Therefore, the process ability of Products on pharmaceutical packaging lines may be compromised. This stickiness and high surface friction can be remediated by covering the surface of the seals with a thin layer of ...