Tablet Formulation Containing Solid Dispersions from Soluplus®

Rubrik: Originale

(Treffer aus pharmind, Nr. 02, Seite 286 (2014))

Reitz E | Djuric D | Kolter K | Thommes M

Tablet Formulation Containing Solid Dispersions from Soluplus® / Reitz et al. • Solid Dispersions · Reitz E, Djuric D, Kolter K, Thommes M · ¹Institute of Pharmaceutics and Biopharmaceutics, Heinrich-Heine-University, Duesseldorf, Germany und ² LB Bohle Maschinen Verfahren GmbH, Enningerloh, Germany und ³ R&D Pharma Ingredients, BASF SE, Ludwigshafen, Germany
Extrusion Kollidon Solid dispersion Solubility Soluplus Tablettes The low aqueous solubility of new chemical entities has been a matter of pharmaceutical research for decades [ 1 ]. Due to the increasing knowledge about the target structures in the human body, drug molecules have become more specific and complex [ 2 ]. This complexity frequently leads to particularly low crystal energy of each drug, which often contributes to low aqueous solubility and low oral bioavailability [ 3 , 4 ]. There are several concepts currently being considered for overcoming this issue, such as complexes- [ 5 ], salts- [ 6 ] ...