Preliminary Studies to Assess Ultrasound-assisted Compaction as a Potential Novel Technique in Solid Dispersion Preparation

Rubrik: Originale

(Treffer aus pharmind, Nr. 04, Seite 652 (2012))

Kalivoda A | Fischbach M | Maio M | Kleinebudde P

Preliminary Studies to Assess Ultrasound-assisted Compaction as a Potential Novel Technique in Solid Dispersion Preparation / Kalivoda et al. • Ultrasound-assisted Compaction · Kalivoda A, Fischbach M, Maio M, Kleinebudde P · ¹Merck Serono, Formulation and Process Development, Darmstadt, Germany und ²Institute of Pharmaceutics and Biopharmaceutics, Heinrich-Heine University, Duesseldorf, Germany
Dissolution Oral drug delivery Polymeric drug carrier Solid dispersion Ultrasound In the last decades, the development of poorly soluble drugs has increased rapidly. Their innovative potential and efficacy notwithstanding, many of these newly developed drugs would never reach the market if it was not for formulations that enhance their in vivo solubility and, therefore, their absorption. Poorly soluble but highly permeable drugs (BCS class II as defined by Amidon in 1995 [ 1 ]) are most suitable for bioavailability enhancement through pharmaceutical formulation. In previously published work, various approaches have been described, for example, particle size reduction by milling, salt ...