The Effect of Tween Excipients on Expression and Activity of P-Glycoprotein in Caco-2 Cells

Rubrik: Originale

(Treffer aus pharmind, Nr. 05, Seite 788 (2014))

Hodaei D | Baradaran B | Valizadeh H | Mohammadnezhad L | Zakeri-Milani P

The Effect of Tween Excipients on Expression and Activity of P-Glycoprotein in Caco-2 Cells / Hodaei et al. • Tween Excipients · Hodaei D, Baradaran B, Valizadeh H, Mohammadnezhad L, Zakeri-Milani P · ¹ Student Research Committee, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran und ² Drug Applied Research Center and School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran und ³ Research Center for Pharmaceutical Nanotechnology and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran und ⁴ School of medicine, Tabriz University of Medical Sciences, Tabriz, Iran. und ⁵ Liver and Gastrointestinal Diseases Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
Bioavailability Caco-2 Excipient P-Glycoprotein Surfactant Tween Having many advantages, like enhanced patient compliance and easier chronic administration, 85 % of drugs sold around the world are administered orally. Oral delivery is the most preferred route in drug prescription but, unfortunately, nearly 50 % of orally administrated drugs have low bioavailability (BA) due to their poor and inadequate absorption through the intestinal mucosa [ 1 , 2 ]. Active efflux of drugs into the gastrointestinal (GI) lumen is generally recognized as a factor for limiting drug absorption and it is responsible for variability in plasma drug concentrations [ 3 ]. An efflux pump, ...