(Treffer aus pharmind, Nr. 03, Seite 485 (2013))
Stratmann A | Dandekar G | Nietzer S
Three-dimensional in vitro Tumor Models as an Alternative for Animal Models in Preclinical Studies / Teil 1 · Stratmann A, Dandekar G, Nietzer S · Chair of Tissue Engineering and Regenerative Medicine, University Hospital Würzburg, Würzburg, Germany
Cancer Cell lines Drug screening In vitro model Tissue engineering Tumor model For over 60 years, human cancer is being investigated by using various in vivo or in vitro models [ 1 , 2 ]. In 1955, the US National Cancer Institute (NCI) started the first large-scale program for drug discovery, during which the effect of various substances on mouse lymphoma models was tested in order to detect new chemotherapeutic agents. Drugs detected or developed during this program, such as anti-mitotic vinca alkaloids, actinomycin D and platinum salts, are still commonly used today [ 1 ]. Few years later, in ...