Sennae fructus

Rubrik: Originale

(Treffer aus pharmind, Nr. 11, Seite 1650 (2016))

Zier K | Schultze W | Sakmann A | Leopold C

Sennae fructus / Analysis and evaluation of the new draft monographs for the European Pharmacopoeia · Zier K, Schultze W, Sakmann A, Leopold C · ¹Division of Pharmaceutical Technology, Department of Chemistry, University of Hamburg, Germany und ²Division of Pharmaceutical Technology, roha arzneimittel GmbH, Bremen, Germany und ³Department of Chemistry, University of Hamburg, Germany
Laxatives Sennae fructus Sennosides HPLC MS The genus Senna belongs to the caesalpiniaceae family and is comprised about 250 species. Two of them are listed in the European Pharmacopoeia: Cassia senna L. (syn. Cassia acutifolia DEL .) also called Alexandrian or Khartoum senna and Cassia angustifolia VAHL , which corresponds to Tinnevelly senna. For these herbal drugs, the following monographs exist: Sennae folium consisting of the dried leaflets [ 1 ], Sennae fructus acutifoliae [ 2 ], Sennae fructus angustifoliae [ 3 ] and Sennae folii extractum siccum normatum [ 4 ]. These Senna drugs belong to the most frequently ...

Direct Compression of Ibuprofen-containing Powder Blends

Rubrik: Originale

(Treffer aus pharmind, Nr. 11, Seite 1842 (2012))

Saniocki I | Sakmann A | Leopold C

Direct Compression of Ibuprofen-containing Powder Blends / Influence of the ibuprofen grade on the flow and compaction properties of an ibuprofen tablet formulation · Saniocki I, Sakmann A, Leopold C · University of Hamburg, Department of Chemistry, Division of Pharmaceutical Technology, Hamburg, Germany
Compactability Deformation Behavior Flowability Heckel Plot Mean Particle Size Sticking Ibuprofen is a non-steroidal drug, which is widely used as an anti-inflammatory analgesic (NSAID). Solid oral dosage forms containing ibuprofen available on the market are tablets, granules, and soft gelatin capsules. Among these, tablets are the most frequently administered pharmaceutical dosage form, because tablets can easily be manufactured in large quantities, and they are easy to handle in terms of storage and distribution [ 1 ]. Further advantages over other dosage forms are the convenient way of administration to patients and the high stability of drug substances in dry formulations. ...