Continuous Atmospheric Droplet-Stream Freeze-Drying Processes

Rubrik: Originale

(Treffer aus pharmind, Nr. 05, Seite 741 (2016))

Süverkrüp R | Wanning S | Lamprecht A

Continuous Atmospheric Droplet-Stream Freeze-Drying Processes / Development and Laboratory System · Süverkrüp R, Wanning S, Lamprecht A · Rheinische Friedrich-Wilhelms-Universität Bonn
Atmospheric lyophilisation Continuous lyophilisation Droplet stream lyophilisation Spray freeze drying Pulmonary drug delivery Uniform spherical porous particles with geometric diameters ranging from about 30–400 μm can be produced in quantities by droplet stream lyophilisation of aqueous solutions containing about 2–10  % of non-volatile solids. In spite of the small size and low density of the particles, the powders are sufficiently stable for handling and have good flow properties. They are readily dispensed and dosed into containers and can be mixed with other disperse solids. In the low size and concentration range, particles with aerodynamic diameters below 5 μm are suited for the pulmonary ...