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Sie suchen in allen Bereichen nach dem Autor Klingler F.
In der Rubrik Zeitschriften haben wir 1 Beitrag für Sie gefunden
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MerkenLife at the periphery
Rubrik: Originale
(Treffer aus pharmind, Nr. 09, Seite 1241 (2021))
Klingler F | Mathias S | Otte K
Life at the periphery / How cell surface proteins can influence bioprocesses · Klingler F1, Mathias S1,2, Otte K1 · 1Institute of Applied Biotechnology, University of Applied Sciences Biberach, Biberach und Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach
Biopharmaceuticals Cell aggregation Cell surface proteins Chinese hamster ovary cells Surfaceome Cell surface proteome Chinese hamster ovary (CHO) cells are currently the main production hosts for biopharmaceuticals. Over the past decades, commercial bioprocesses have been steadily optimized to create optimal environments for the cultured cells to grow in suspension, stay viable and produce desired products at high titres and quality. However, the suspension-adapted CHO cells were originally derived from a spontaneously immortalized putative epithelial cell and sometimes regress into patterns forming large cell aggregates. This cell adhesion and aggregation may result in loss of cell viability and/or a decrease in ...
