Comparison of the Performance of Single Punch and Rotary Tablet Presses from Different Vendors

Rubrik: Maschinen- und Anlagenbau

(Treffer aus TechnoPharm, Nr. 02, Seite 96 (2018))

Zimmermann M | Schaldach G | Thommes M | Bauer-Brandl A | Kleinebudde P

Comparison of the Performance of Single Punch and Rotary Tablet Presses from Different Vendors / Zimmermann et al. • Comparison of Tablet Presses · Zimmermann M, Schaldach G, Thommes M, Bauer-Brandl A, Kleinebudde P · Department of Biochemical and Chemical Engineering, TU Dortmund University, Dortmund (Germany) und Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Odense und Institute of Pharmaceutics and Biopharmaceutics, Heinrich-Heine-University, (Denmark) und Düsseldorf (Germany)
Tablets Tensile strength Rotary tablet presses Single punch tablet presses Force-time profiles Tablets are solid single unit dosage forms made from dry powder blends or granules using high compression forces [1]. They are the most common drug delivery systems today: According to the International Association for Pharmaceutical Technology (APV) about 80 % of the produced dosage forms are solid [2]. Tablets offer a number of advantages: They have a high level of patient compliance. In addition, tablets are typically of excellent dosing accuracy, easy to pack, to store, and to transport [3]. A high production rate is realized on rotary presses, ...

Tablet Formulation Containing Solid Dispersions from Soluplus®

Rubrik: Originale

(Treffer aus pharmind, Nr. 02, Seite 286 (2014))

Reitz E | Djuric D | Kolter K | Thommes M

Tablet Formulation Containing Solid Dispersions from Soluplus® / Reitz et al. • Solid Dispersions · Reitz E, Djuric D, Kolter K, Thommes M · ¹Institute of Pharmaceutics and Biopharmaceutics, Heinrich-Heine-University, Duesseldorf, Germany und ² LB Bohle Maschinen Verfahren GmbH, Enningerloh, Germany und ³ R&D Pharma Ingredients, BASF SE, Ludwigshafen, Germany
Extrusion Kollidon Solid dispersion Solubility Soluplus Tablettes The low aqueous solubility of new chemical entities has been a matter of pharmaceutical research for decades [ 1 ]. Due to the increasing knowledge about the target structures in the human body, drug molecules have become more specific and complex [ 2 ]. This complexity frequently leads to particularly low crystal energy of each drug, which often contributes to low aqueous solubility and low oral bioavailability [ 3 , 4 ]. There are several concepts currently being considered for overcoming this issue, such as complexes- [ 5 ], salts- [ 6 ] ...